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Phenelzine/Nardil : Wheeless' Textbook of Orthopaedics
The Hip - book
Home » Ortho Related » Medications » Phenelzine/Nardil

Phenelzine/Nardil



Phenelzine is a MAOI;
DOSING INFORMATION:  Recommended oral adult doses of phenelzine are 45 to 75 mg/day; alternatively,
- Onset of activity is noted within 2 weeks, however, maximal effects are not seen until up to 6 weeks of therapy.
    - Phenelzine is well absorbed following oral administration and is excreted primarily as metabolites in the urine.
- Phenelzine should be used cautiously in combination w/ tricyclic antidepressants or other MAO inhibitors; foods with a high tyramine content should be avoided.
- Frequent adverse effects of phenelzine include orthostatic hypotension, drowsiness, dizziness, mania, agitation, and weight gain.
- anticholinergic agents be avoided whenever possible;
- meperidine should definitely be avoided, whereas  fentanyl or morphine appear to be suitable during Hanesthesia;
- enflurane or isoflurane are preferred over halothane because of reduced arrhythmogenic potential;
- due to the possibility of hypotension associated with spinal and epidural anesthesia and the subsequent requirement for basopressors general anesthesia is preferred.



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