– Contraindications same as Heparin: – ASA (Bleeding) – w/ hemorrhagic tendencies – pregnancy – severe hepatic or renal disease – severe hypertension – blood dyscrasis – Agents which Increase Prothrombin Time: – Acetaminophren; – Allopurinol – ASA – Steroids – Cimetidine – Indomethacin – Flaggyl – Hypoglycemics – Phenothiazines – Phenylbutazone – Propylthiouracil – … Read more
– Discussion: – it is also required in appropriate amounts for membrane stability; – excess or defeciency may lead to rupture of lysosomal membranes; – Vit A participates in the biology of epithelium, and in excess it causes proliferation of basal cells and hyperkeratinization; – Toxicity: – causes increased intracranial pressure, vomiting, and lethargy Effect … Read more
– See: – Class IV Agents – Discussion: – Ca channel blocker, prolongs AV conduction, slows sinus rate, & exerts Negative Inotropic effect; – Useful for converting narrow complex SVT to sinus rhythm in stable patients if carotid sinus massage unsuccesful; – Useful for Unstable Angina, HTN, A.fib & A. Flutter (except when A.fib/flutter is … Read more
– Discussion: – for penicillin resistant to staph – MSSA / MRSA – and w/ enterococci endocarditis (in combination with aminoglycosides); – it is ineffective against gm neg bacterial (its large molecular weight keeps it from penetrating the outer cell membrane of gram-negative bacilli); – basic science: – blocks glycopeptide polymerization in … Read more
– Discussion: (see vancomycin and addition of antibiotics to cement, vanc in ca sulfate and local delivery of antibiotics to infected joints): – dosing: – as much as 4 gm of vancomycin (as well as 4.6 gm of tobramycin) can be used per batch of cement; – note that the cost for a 1 … Read more
– Discussion: – has been taken of of the maket due to liver toxicity; – a type of PPAR gamma activator which blocks insulin resistance, and allows lower dosages of insulin without loss of efficacy; – may also be given with … Read more
– for pruritis associatted with allergic and nonallergic conditions; – acts as antihistamine of phenothiazine type; – Adult: 2.5mg PO qid PRN or 5mg PO q12hr sustained realease; – Note that extrapyrimidal effects may occur in the elderly
– See: After-Loading Agents: – Discussion: – for production of controlled hypotension during surgery; – treatment of HTN Crises, HTN, pulmonary hypertension; – note additive effect w/ other Antihypertensive agents; – Adults: 0.5-1mg/min IV infusion titrated to effect
– for control of NAUSEA and VOMITING; acts on trigger zone in medulla oblongata, determine etiology of vomiting before using Antiemetics; – Dosage: 250mg PO tid to qid; Injection:200mg IM tid/qid
– Discussion: – for UTI, otitis media, acut exacerbation of chronic bronchitis, pneumocystis carini; – has an excellent spectrum of activity against beta lactamase-producing staph, and can be effective as an antistaphylococcal agent; – septra not effective vs. group A strep; – adult dose: … Read more