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Teratogenic, contraindicated in pregnant women; 
Gum should be chewed slowly until sense tingling or pepery taste (one minute), then park the gum between cheek and gum; once the tingling or tast is gone, then rebegin chewing until again senses taste; 
This should be repeated for about 30 minutes; 
Ea nicorrette contains equivalent of 2mg Nicotine; 
May take up to 10-12 pieces of gum/day; 
Contraindicated in nonsmokers, pt w/significant cardiac problems, pregnancy; 
Will contribute to cardiac problems, problems w/ adrenal medulla, hyperthryroidism, IDDM, PUD