Home » Ortho Related » Medications » Famotidine/Pepcid Famotidine/Pepcid - For short term treatment of active duodenal ulcer; - Active ulcer: 40mg PO HS or 20mg PO bid for 4-8 wks then 20mg PO HS; - Decrease dose with severe renal failure - Unlike Cimetidine is not an inhibitor of the cytochrome P450 system