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CLOZAPINE/CLOZARIL



- antipyschotic med, for chronic pyschotic patients who are resistant to usual medications; Both active and passive symptoms may improve with this medication;
- Side effects include Agranulocytosis in 1-2% of patients;
- WBC < 3000 or ANC < 1500 calls for interuption of treatment;
- Also note dose related increase risk of seizures;
- at 300mg/day, increase risk of seizure is 1-2%; at 600mg/day incr risk is 3-4%;
- Marked sedation, tachycardia, and hypotension are also seen