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Chlorpromazine/Thorazine


- may be used to control severe HTN which does not respond to Nitroprusside, use Thorazine w/ caution;
    - begin w/ 2.5 mg IV bolus, repeating prn q 5-10 min to max dose of 15 mg;
    - must have liter of crystaloid ready for infussion, if profound hypotension occurs;
- for psychotic, Nausea, Vomiting; Adult anxiety: 10-25mg PO bid/tid;
- severe symptoms: 25mg IM, can repeat in 1 hr, then 25mg PO bid/tid;
- Note Side Effects: Sedative=Strong; Hypotensive=Strong; Anticholinergic=Intermediate;  EPS=Weak;
- Note: lowers Seizure Threshold;
- Peds: > 6 months: 0.55 mg/kg/dose q6-8hr IM or IV; maximum of 40 mg/24hrs for < 5yrs or 75 mg/24hrs for 5-12 yrs; 0.5mg/kg/dose PO q4-6hr


Intramuscular meperidine, promethazine, and chlorpromazine: analysis of use and complications in 487 pediatric emergency department patients.