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Antimalarials


- clinical response can be anticipated within three to six months after initiating therapy with approximately 40%-60% of patients able to expect a beneficial response.
- upper end of dosage used in treatment of RA is 3-4 mg/kg/day for chloroquine and 6-7.5 mg/kg/day for hydroxychloroquine;
- corneal deposits occur in up to 50% of patients receiving antimalarial drugs but these do not generally cause visual impairment; these deposits are reversible and not a contraindication to sustained therapy