- mitotic rate of regenerating epidermal cells increased 5-10 fold in moist, O2 rich environment as compared to desiccated wound environment; - in experimental wounds the local pO2 is 0-20 as compared to 30-60 mm in the normal tissues;
- pCO2 in the wound is 60 mm with a pH of 7.1;
- Methods of Oxygen Delivery:
- its difficult to reliably to deliver > 50% O2 except by endotracheal tube;
- Role of Oxygen Tension in Wound Healing:
- "100% face mask" usually only gives 40 to 50% actual O2 concentration;
- its difficult to cause O2 toxicicty w/ a mask, since concentration is < 50%;
Type FiO2 Discussion
Nasal Cannula uncertain FiO2 Do not use > 5 lit NC Reservoir type uncertain FiO2 Trans-tracheal Flow rates of 0.25-3.0 lit/min; cannula Ventimask Available at 24, 28, 31, provides controlled FiO2; 35, 40, & 50% may need to humidify O2; High humidity 28 to 100 % O2 mask Reservoir mask > 90 % O2 Delivery Nonbreathing Partial rebreathing T tube
The effect of differing ambient oxygen tensions on wound infection.
Assessment of perfusion in postoperative patients using tissue oxygen measurements.
Local heat increases blood flow and oxygen tension in wounds.
Direct measurement of wound and tissue oxygen tension in postoperative patients.
Special Topic: Hyperbaric Oxygen Therapy in Plastic Surgery: A Review Article.
Oxygen as an isolated variable influences resistance to infection.
Oxygen as an antibiotic. A comparison of the effects of inspired oxygen concentration and antibiotic administration on in vivo bacterial clearance.
Directly measured tissue oxygen tension and arterial oxygen tension assess tissue perfusion.
The dynamic properties of tissue oxygen in healing flaps.
Tissue oxygenation, anemia, and perfusion in relation to wound healing in surgical patients.
The role of oxygen-derived free radicals in the management of venous (varicose) ulceration: a new approach.
The influence of epidermal thickness on transcutaneous oxygen pressure measurements in normal persons.
High-dose magnesium sulfate attenuates pulmonary oxygen toxicity.