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Mechanisms of Bone Resorption

- Discussion:
- bone resorption involves the dissolution of mineral crystals along w/breakdown of the bone matrix;
- calcium is probably removed before the matrix is degraded, yet these events are closely linked;
- once bone mineral dissolution has begun, collagenolytic enzymes may act on the insoluble collagen molecules and convert them to large,
soluble fragments;
- collagenase, cathepsin D, acid protease, acid phosphatase, deoxyribonuclease, and other acid hydrolases may be in further degradation of
collagen fragments;
- resorption is enhanced by acidosis and inhibited by alkalosis;
- low pH may be required as initial step in mobilization of calcium;

- Methods to Quantify Resorption:
- urinary hydroxprolene;
- urinary pyridinoline
- urinary deoxypyridinoline