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Etidronate Sodium (Didronel)


- Discussion:
- contains either 200mg or 400mg = diphosphonic acid:
- it can inhibit bone resorption and formation
- Paget's Disease:
- measure Alk Phos and bone scans to judge efficacy;
- dose: 5-10  mg/kg/day PO - not to exceed 6 months 11-20 mg/kg/day PO - not to exceed 3 months;
- may restart treatment after 90 days, if there is efficacy;
- Heterotopic ossification:
- THR: - 20 mg/kg/day PO for 1 month before and 3 months after surgery
- Spine Trauma - 20 mg/kg/day for 2 weeks, then 10 mg/kg/day for 10 wks