- 2.5 to 5 mg for children & 2.5 mg to 10 mg for adults;
- continuous infusion of large amounts of methotrexate may be employed (from 250 mg to 1 g/sq m., q week), when leucovorin rescue is used.
- supplemental folic acid (1 mg/day) will reduce risk of hematologic
toxicity without interfering with efficacy.
- scored 2.5 mg tabs and also as a dry powder containing 20 to 250 mg vials;
Diagnosis and Treatment: Methotrexate in Rheumatoid Arthritis: Indications, Contraindications, Efficacy, and Safety.
Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric
Rheumatology Collaborative Study Group and The Cooperative Children's Study Group.