- Contraindications same as Heparin: - ASA (Bleeding) - w/ hemorrhagic tendencies - pregnancy - severe hepatic or renal disease - severe hypertension - blood dyscrasis
- Agents which Increase Prothrombin Time: - Acetaminophren; -
Allopurinol -
ASA -
Steroids -
Cimetidine - Indomethacin - Flaggyl -
Hypoglycemics - Phenothiazines - Phenylbutazone - Propylthiouracil - Quinidine - Salicylates - Tricyclics - Septra;
- Agents which Decrease Prothrombin Time: - Barbituates - Oral contra-ceptives -
Rifampin - Hypothroid patients may be Resistant to Coumarin; - High levels of Ascorbic acid will interfere with effects;
