- See: Theophylline Preparations:
Drug Interactions and Toxicities:
Aminophylline;
- Discussion: - for prevention of bronchial
Asthma, reversible
bronchospasm assoc w/ chronic bronchitis and emphysema; - is direct relaxant of smooth muscle of bronchial airway & pulmonary blood vessels (bronchodilator and smooth muscle relaxant);
- Adult Dose: - can only begiven PO; - 24mg/kg/24hrs PO divided dose or q6hr SR: q8-12hr; -
loading dose for acute
bronchospasm: 5mg/kg PO -
maintenance dosage: for chronic
Asthma: - 400 mg/day PO in divided doses (e.g. Theodur 200mg bid); - for smokers = 0.83 mg/kg/hr, healthy adult = 0.53 mg/kg/hr, - for elderly patients: 0.26 mg/kg/hr PO;
- Peds: 10-20 mg/kg/day q 6hr; supplied: liq 80 mg/15 cc tab 30, 60 mg;
- Monitor Theophylline Plasma Levels: - therapeutic is 10-20 ug/ml or 30-100 mmol/l; - greater than 20 ug/ml is toxic; and adjust dosage accordingly;
Theodor: - 15-20 mg/kg/day q 12hr - tab 100, 200, 300 mg; -----------------------------------
Original Article: A Randomized, Controlled Trial Of Theophylline In Patients With Severe Chronic Obstructive Pulmonary Disease.
