Telangiectatic Osteosarcoma


- Discussion:
    - an uncommon type of osteosarcoma w/ early pulmonary metastasis & an especially poor prognosis;
    - telangiectatic osteosarcoma has a complex karyotypes with multiple chromosomal abnormalities.

- Differential Dx:
     - Aneurysmal bone cyst;
           - this is both radiographically and pathologically similar to telangectatic osteosarcoma;
           - unlike osteosarcoma, ABCs appear to be karyotypically normal;

- Histology:
    - characterized by loose sarcomatous stroma w/ septa and spaces along w/ ectatic blood vessels (similar to ABC);
    - high anaplastic tumor cells, malignant giant cells & pathologic mitotic figures;
    - osteoid production may be minimal;

- Radiographs:
    - highly destructive lesion


Telangiectatic osteogenic sarcoma of the extremities. Results in 17 patients treated with neoadjuvant chemotherapy.

Telangiectatic osteosarcoma.

Osteosarcoma with small cells simulating Ewing's tumor.



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Thursday, June 7, 2012 4:21 pm