- Discussion: - for short term treatment of
duodenal ulcers, gastric ulcers, - provides local acid resistant barrier, inhibits pepsin; - constipation may be a frequent side effect; - may be of benefit in intubated patients - does not increase gastric pH
- because of risk of aluminum toxicity, (released when compound ionizes), sucralfate is not used in
renal failure; - do not use w/ gastric stasis (may give rise to benzoars);
- Adult Dosing: - 1gm PO qid, 1 hr AC and HS; - should be taken on an empty stomach; - antacid may also be used if taken 1/2 hr prior to or after sucralfate; - treatment should be continued for 4-8 weeks;
Carafate: Drug Interactions and Toxicities: - Absorption & Bioavailability of following are Reduced: - Ciprofloxacin and Norfloxacin -
theophylline and Aminophylline - Tetracycline - Phenytoin -
Digoxin - Amitriptyline - (the bioavailability of
Digoxin, tetracycline, and phenytoin was not reduced when they were given two hours before sucralfate) ------------------------------------------
Sucralfate does not reduce the risk of acid aspiration pneumonitis. 
