Sucralfate/Carafate


 - Discussion: 
- for short term treatment of duodenal ulcers, gastric ulcers, 
- provides local acid resistant barrier, inhibits pepsin; 
- constipation may be a frequent side effect; 
- may be of benefit in intubated patients 
- does not increase gastric pH 
- because of risk of aluminum toxicity, (released when compound ionizes), sucralfate is not used in renal failure
- do not use w/ gastric stasis (may give rise to benzoars); 
- Adult Dosing: 
- 1gm PO qid, 1 hr AC and HS; 
- should be taken on an empty stomach; 
- antacid may also be used if taken 1/2 hr prior to or after sucralfate; 
- treatment should be continued for 4-8 weeks; 
Carafate: Drug Interactions and Toxicities: 
- Absorption & Bioavailability of following are Reduced: 
- Ciprofloxacin and Norfloxacin 
- theophylline and Aminophylline 
- Tetracycline 
- Phenytoin 
- Digoxin 
- Amitriptyline
- (the bioavailability of Digoxin, tetracycline, and phenytoin was not reduced when they were given two hours before sucralfate) 


Sucralfate does not reduce the risk of acid aspiration pneumonitis.

 




Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Monday, December 19, 2011 1:02 pm