- Discussion: - for primary hyperaldosteronism,
HTN, CHF, Cirrhosis; - also used for diuretic induced
hypokalemia when oral supplements or other potassium sparing agents are inappropriate; - diruetic of choice for cirrhotic edema and ascites;
- Adult: Edema: - 25-200 mg/day administered in single or divided doses; - if diuresis remains inadequate, add 2nd diuretic agent w/ action more proximal in the renal tubule;
- HTN: - 50-100mg/day initially; adjust dose after 2 weeks; - add 2nd diuretic agent w/ action on proximal renal tubule if
HTN persists; - or... 25-100mg/24hr PO in divided doses; - max dose: 400mg/day for primary hyperaldosteronism; - may take upto 3-4 days for diuretic effect; - Contraindicated with anuria,
hyperkalemia, renal impairment;
