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Wheeless' Textbook of Orthopaedics

Rx of Atrial fibrillation


- See: - A. Flutter - Causes of A. fib - r/o WPW as a predisposing cause; - If Unstable (or onset < 3 days): Cardio Convert (100 J) - If Stable: (w/ rates greater than 100/min) Consider - Digoxin: to slow the AV conduction rate - Propanolol: - Diltiazem - Verapamil: - combination of Digoxin, Verapamil, and Beta blocker can lead to complete heart block, while Verapamil and propanolol can lead to sinus arrest; - After Slowing of AV conduction; - quinidine: may be used only after stabilization w/ Digoxin - Procainamide - either of these meds may convert A. fib to Normal Sinus Rhythm; - Class I agents should be withheld until adequate control of AV conduction has been obtained, as they enhance AV conduction; - New Onset Stable A. fib: - rate < 145, SBP > 100, & pt is awake, alert, and has no angina; - treatment is rapid Digitalization; - give 0.5 mg IV initially and 0.25 mg IV q6 hr for 2 or 3 additional doses for a total of 1 mg or 1.25 mg; - peak effect may not take effect for 90 to 120 min; - if patient does not slow after the initial Digoxin dose, additional drug may be given 0.25 mg IV q2hr until the heart rate slows;



Original Text by Clifford R. Wheeless, III, MD.