- maximum dose for RA patients is 750 mg to 1 g per day;
- low doses (125-250 mg) of the drug are used initially with slow-dose titration to reduce the potential for side effects.
- D-penicillamine exhibits similar toxicity profile to IM gold, which includes mucocutaneous reactions, proteinuria, nephrotic syndrome, leukopenia, thrombocytopenia, and rarely, aplastic anemia.
- may cause autoimmune reactions, SLE, myasthenia gravis, polymyositis, & Goodpasture's syndrome.
Original Text by Clifford R. Wheeless, III, MD.
Last updated by Data Trace Staff on Thursday, June 9, 2011 10:27 am