Pathophysiology of Gout

- Discussion:
    - humans lack the enzyme uricase which is involved in elimination of excess nucleic acid purines & nitrogenous waste products through 
           production and excretion of allantoic acid;
            - hence in humans, uric acid is end product of purines degradation;
    - gouty arthritis begins w/ deposition of MSU crystals in synovial & periarticular tissue;
    - factors related to microtophus formation:
           - reduced solubility of MSU at the periphery of the body because of lower temperatures;
           - weight bearing (MTP joint incurs high force / area)

Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, September 13, 2011 1:53 pm