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Wheeless' Textbook of Orthopaedics

Osteomalacia from Chronic use of Anticonvulsant Medication






- Discussion:
    - rickets or osteomalacia may occur from most anticonvulsants;
    - disorder is common and may be present in upto 15 % of pts;
    - syndrome is dangerous because of increased sensitivity of central nervous
            system that occurs with lowering of serum Ca concentration;
    - disorder can be corrected by administration of 1,25-dihydroxyvitamin D;




Original Text by Clifford R. Wheeless, III, MD.