Nucleus pulposus

- Discussion:
    - nucleus pulposus consists of a network of delicate collagenous fibers in a mucoprotein gel rich in polysaccharide;
    - contains type II collagen;
    - nucleus has a high water content, apparently the result of imbibition by the gel;
    - it functions to resist compressive loads;
    - water content declines with advancing age and is reduced by pressure borne by the disc, accounting for loss in the height of a person 
           during an active day;
           - gradual loss of proteoglycan content explains the loss of water w/ aging;
           - after the third decade, there is gradual loss of fluid and concomitant fibrous replacement of the nucleus;
           - by sixth or seventh decade the nucleus has become fibrocartilage;
           - w/ age, the anulus shows coarsened and hyalinized fibers and fissuring of the lamellae;

- Herniation:
    - herniation of intervertebral disc occurs most often in lumbar or cervical regions where motion and stress are greatest;
    - this may involve a simple bulging of the disc or complete herniation of a portion of the nucleus pulposus through the anulus fibrosus

Glutathione protects human nucleus pulposus cells from cell apoptosis and inhibition of matrix synthesis

Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Monday, May 21, 2018 7:57 am