- direct acting arterial & venous dilator is treatment of choice for HTN crises;
- if HTN remains, despite max dosing then use Chlorpromazine;
- consider Hydralazine when weaning from drip;
- w/ Aortic dissection, Nitroprusside useful, but must be used with Beta blocker-
-reduces Intra Vent Press and Shearing Force;
- Acute MI; CHF;
- Adult Dosing:
- 0.5 - 10 ug/kg/min IV infusion (0.5 ug/kg/min = 10 ml/hr) titrated to effect;
- avg dose of 1-3ug/kg/min will usually lower diastolic pressure by 30-40%;
- note: w/ d/c of IV, effects end in 5 min;
- infusions must be protected from light;
- Peds: 0.5-10 ug/kg/min IV infusion; average of 1.0-3.0 ug/kg/min;
- Supplied as 5 ml vials containing 50 mg Na Nitroprusside to be reconstituted with sterile 5% dextrose in H20; (eg. 50mg / 250ml of D5W)
Use of vitamin B12 in the treatment and prevention of nitroprusside-induced cyanide toxicity.
Original Text by Clifford R. Wheeless, III, MD.
Last updated by Data Trace Staff on Friday, December 16, 2011 4:12 pm