- See: -
After-Load -
Toxicity - Discussion: - direct acting arterial & venous dilator is treatment of choice for
HTN crises; - if
HTN remains, despite max dosing then use
Chlorpromazine; - consider
Hydralazine when weaning from drip; - w/ Aortic dissection, Nitroprusside useful, but must be used with
Beta blocker--reduces Intra Vent Press and Shearing Force; - Acute
MI; CHF;
- Adult Dosing: - 0.5 - 10 ug/kg/min IV infusion (0.5 ug/kg/min = 10 ml/hr) titrated to effect; - avg dose of 1-3ug/kg/min will usually lower diastolic pressure by 30-40%; - note: w/ d/c of IV, effects end in 5 min; - infusions must be protected from light; -
Peds: 0.5-10 ug/kg/min IV infusion; average of 1.0-3.0 ug/kg/min; -
Supplied as 5 ml vials containing 50 mg Na Nitroprusside to be reconstituted with sterile 5% dextrose in H20; (eg. 50mg / 250ml of D5W) --------------------------
Use of vitamin B12 in the treatment and prevention of nitroprusside -induced cyanide toxicity.
