- Dosing:
- leukemia:
- 2.5 to 5 mg for children & 2.5 mg to 10 mg for adults;
-
continuous infusion of large amounts of methotrexate may be employed (from 250 mg to 1 g/sq m., q week), when leucovorin rescue is used.
- supplemental
folic acid (1 mg/day) will reduce risk of hematologic
toxicity without interfering with efficacy.
- Supplied:
- scored 2.5 mg tabs and also as a dry powder containing 20 to 250 mg vials;
- Drug Interactions and Toxicity:
Diagnosis and Treatment: Methotrexate in Rheumatoid Arthritis: Indications, Contraindications, Efficacy, and Safety.
Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model.
Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric
Rheumatology Collaborative Study Group and The Cooperative Children's Study Group.
Comparison of auranofin, methotrexate, and the combination of both in the treatment of rheumatoid arthritis. A controlled clinical trial.
Influence of methotrexate and azathioprine on radiologic progression in rheumatoid arthritis. A randomized, double-blind study [see comments.
