Orthopaedic Jobs

Mechanisms of Mineralization



- See: Essentials in Osteodynamics

- Discussion:
    - tissue mineralization is considered to be last step in bone formation;
    - principal mineral salt of bone exists primarily in form of crystalline hydroxyapatite, which is thermodynamically stable phase at normal 
         tissue pH;
    - first step in the precipitation of bone salts must involve some type of nucleation, that is, the formation of a mineral arrangement of calcium 
         and phosphate ions capable of crystal growth;
    - phenomenon of nucleation of "seeding" is explained by the concept of undersaturation of body fluids with calcium and phosphate until the
         first precipitate is formed



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, September 13, 2011 1:24 pm