- See:
Essentials in Osteodynamics
- Discussion:
- tissue mineralization is considered to be last step in bone formation;
- principal mineral salt of bone exists primarily in form of crystalline
hydroxyapatite, which is thermodynamically stable
phase at normal tissue pH;
- first step in the precipitation of bone salts must involve some type
of nucleation, that is, the formation of a mineral arrangement of
calcium and phosphate ions capable of crystal growth;
- phenomenon of nucleation of "seeding" is explained by the concept of
undersaturation of body fluids with calcium and phosphate until the
first precipitate is formed;
