Mechanisms of Bone Resorption



- Discussion:
    - bone resorption involves the dissolution of mineral crystals along w/breakdown of the bone matrix;
    - calcium is probably removed before the matrix is degraded, yet these events are closely linked;
    - once bone mineral dissolution has begun, collagenolytic enzymes may act on the insoluble collagen molecules and convert them to large,
            soluble fragments;
    - collagenase, cathepsin D, acid protease, acid phosphatase, deoxyribonuclease, and other acid hydrolases may be in further degradation of 
          collagen fragments;
    - resorption is enhanced by acidosis and inhibited by alkalosis;
          - low pH may be required as initial step in mobilization of calcium;

- Methods to Quantify Resorption:
    - urinary hydroxprolene;
    - urinary pyridinoline
    - urinary deoxypyridinoline



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, September 13, 2011 1:25 pm