Ortho-Preferred

Mastocytosis



- Discussion:
    - characterized by increased numbers of mast cells in vicera, principally liver, spleen, GI tract, and lymph nodes;
    - skin may show numerous hyperpigmented macules that reflect dermal mast cell accumulation;
    - symptoms of systemic mastocytosis are largely attributable to release of mediator substances from mast cells and include generalized puritis, uticaria, flushing, epsidotic hypotension, peptic ulcer, and syncope;
    - skeletal manifestations include bone pain, tenderness, and deformity due to fracture;

- Radiographs:
    - diffuse poorly demarcated sclerotic and lucent areas that involve axial skeleton

   



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Thursday, May 10, 2012 4:27 pm