Lupus Anticoagulant



- See: Antiphospholipid Antibodies

- Discussion:
    - is antibody acting on phospholipid of prothrombin activator complex causing an in vitro anticoagulant effect that paradoxically is associated with thrombosis in vivo;
          - patients may demonstrate venous and arterial thrombosis and thrombocytopenia;
    - there is no agreement as to which group of tests is more sensitive to measure lupus erythematosus anticoagulant;
    - plasma showing abnormal activated partial prothrombin time, a positive screening test for lupus anticoagulant, & no evidence of fibrin-fibrinogen degradation products is considered positive for lupus erythematosus anticoagulant;
    - patients with lupus average have frequency of 34% for lupus erythematosus anticoagulant and 44% for anticardiolipin antibodies



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, September 4, 2012 11:21 am