- Local Anesthetic Actions
- Systemic Actions:
- see:
class I cardiac agents
- for management of
ventricular ectopy ( >5
PVC/min or any
PVC after acute
MI) including
VT &
V Fib;
-
initial bolus:
- given as a bolus of 1 mg/kg (50-100mg) initially;
- additional boluses of 0.5 mg/kg are given subsequently (q8-10 min) to total dose of 3 mg/kg as needed;
- ET & IV push given undiluted;
-
maintenence drip:
- constant infusion at 2-4 mg/min;
- dilution for infusion: 1 gm/250 ml D5W (= 4mg/ml);
- peds: 1mg/kg dose IV, then 30 ug/kg/min drip;
- supplied: injection: 1%, 2%, 4%, 10%, 20%;
- precautions:
- dosage reduction required w/ liver disease, elderly, CHF;
- signs of toxicity include dizziness, confusion, slurred speech, paresthesias,
convulsions and hypotension;
- toxic levels: >6-8ug/ml;
