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Wheeless' Textbook of Orthopaedics
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Hemangioma of Bone



- See: Hemangioma of Soft Tissue

- Discussion:
    - typically seen in asymptomatic patients;
    - symptomatic patients over 40 years old may present following small spine fractures;
    - hemangiomas affect bone are rare;
    - these tumors may be located on the periosteal surface, within the cortex, or within the medullary canal;

- Hemangioma of Spine:
    - hemangiomas are usually located in lower thoracic spine & are found in 11 % of spines examined post mortem;
    - they are generally asymptomatic; when symptoms do occur they are due to vertebral collapse or expansion of tumor into the spinal canal;
    - radiographs:
          - classically has "jail house striations" on plain films &
          - typical radiographic image of a hemangioma shows vertical striations, and the CT scan usually demonstrates the vertical
                  trabeculae with intervening soft-tissue or fat attenuation;
      - CT scan:
            - key finding is "spikes of bone" w/ in vertebral body;
      - MRI:
            - shows markedly increased signal intensity on T1 images & T2 images;
            - hemorrhage and thrombosis can also cause increase in signal intensity on T1 images;
      - treatment:
            - treatment is observation, and radiation therapy in cases of persistent pain on pathologic diagnosis;
            - in some cases, vascular embolization is indicated, either as a definative means of treatment or as a means of
                    reducing blood loss during surgery;
            - anterior resection and fusion are reserved for refractory cases or pathologic collapse and neural compression;
            - in the report by JD Heiss MD et al NEJM, the authors report on injection of ethanol into vertabral hemangiomas;
                    - two patients underwent these injections with improvement in their condition being maintained for over three years;
                    - they noted that in a larger series that 2 out of 7 patients had compression fractures which complicated their treatment;
                    - references:
                          - Treatment of Vertebral Hemangioma by Intralesional Injection of Absolute Ethanol
                                  John D. Heiss, M.D.   The New England Journal of Medicine -- May 16, 1996 -- Vol. 334, No. 20
                          - Relief of spinal cord compression from vertebral hemangioma by intralesional injection of absolute ethanol.
                                  Heiss JD, Doppman JL, Oldfield EH.   N Engl J Med 1994;331:508-11.
                          - Vertebral hemangioma with compression fracture and paraparesis treated with preoperative embolization and vertebral resection.
                                  Graham JJ, Yang WC.   Spine 1984;9:97-101.




Malignant hemangioendothelioma of bone.

Massive Osteolysis of the femur (Gorham's disease): a case report and review of the literature.
      AA Mendez, D Keret, W Robertsn et al.   J. Pediatric Orthopedics. Vol 9. 1989. p 604-608.

Preoperative endovascular embolisation of a vertebral hemangioma.
      VW NG et al.   JBJS. Vol 79-A. No 5. Sep 1997. p 808.
 
Surface hemangiomas presenting as bone lesions.
      Scott WeinerMD and Pravin Muniyappa.   Orthopedics.   May 1999. Vol 2. No 5.   539.









Original Text by Clifford R. Wheeless, III, MD.