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Wheeless' Textbook of Orthopaedics
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Fresh Frozen Plasma


- See: - WARFARIN - Coags - Transfusion Therapy - Volume: Approximately 200mL; - Dose: 2 units FFP - Maximum admistration time: 4 hrs; - Rate of infusion: depends on patient's clinical condition; - Indications: Bleeding w/ labile Coagulation factor deficiencies; (Factor V or VIII) - Note: Must allow 20-30min to thaw; - FFP contains all clotting factors including the labile factors V and VIII as well as 250 to 400 mg of Fibrinogen; - FFP contains anti-erythrocyte antibodies, & is given type specific product; - after every 6 units of blood is given, two units of FFP is given, and after every ten units of blood, six units of platelets should be infused; - effectiveness of FFP will lapse within hours, requiring administration; - FFP has been associatted with non cardiac pulmonary edema; - one should not administer FFP to correct clotting studies unless the patient shows excess bleeding; ----------------------------------- Effect of fresh-frozen plasma resuscitation on cardiopulmonary function and serum protein flux. Fresh frozen plasma supplement to massive red blood cell transfusion.



Original Text by Clifford R. Wheeless, III, MD.