Fluoxetine/Prozac



- Discussion:
    - anti-depression medication:
    - is a selective serotonin uptake inhibitor;
    - adult: 20mg / 24 hr PO qAM initially; titrate to max dose of 80 mg/24hr;
    - note nausea, nervousness, weight loss common;
    - note side effects: sedation: +; insomnia: +++; anticholinergic: 0;
    - check LFT's; Pt not to have ETOH;
    - fluoxetine may dramatically increase tricyclic antidepressant concentration by upto 5 fold;
    - increase in concentration of haldol are also seen w/ use of Prozac;
    - MAOI combined with fluoxetine may cause development of serotonin syndrome-like illness characterized by anxiety, restlessness, confusion, chills, incoordination, and insomnia;
    - combination of fluoxetine and lithium or carbamazepine may also provoke serotonin syndrome



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, July 3, 2012 1:34 pm