- See 
- Captopril - Antihypertensives 
- for HTN, CHF; ACE;
- Adult: w/ Diuretics initially 2.5mg/day PO titrated to BP; 
- Adult w/ no diuretic then intial dose: 0.5mg/day PO titrated to BP; 
- Max dose = 40mg/day divided dose; 
- Injection dose: 0.625 mg to 1.25mg IV q6hr over 5 min; - titrate to effect (SBP) by 0.625 mg increments; 
- when patient is ready for PO form, switch to Captopril (10 times IV dose); 
- Precautions: 
- intital dose may give symptomatic hypotension, esp w/ Diuretics;

- attempt to d/c diuretics 2-3 days before intiating ACE; 
- contraindicated with impaired renal function or renal artery stenosis; 
- d/c if laryngeal edema/angioedema occurrs; 
- may cause cough, and note that the vasotec is preferable to Captopril for patients with collagen vascular dz

Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Wednesday, December 14, 2011 4:27 pm