- See:
Tetracycline
- Discussion:
- broad spectrum antibiotic, for rickettsiae, chlamydia, mycoplasma pneumoniae, bacteroides,
useful for chronic bronchitis, & prostatitis;
-
tetracycline of choice w/ renal impairment; long acting;
- adult: 100mg PO q12hr/day #1, then, 100mg/day or 50mg/day PO bid or 100-200mg/day IV qd;
- renal failure; 60mg PO qid;;
- ratio of CSF to blood level (%): normal meninges: 13;
- inflammed meninges: 18; dosing regimens for patients with renal
- insufficiency (dose for 70kg adult {gm/dosing interval in hours}):
CrCl >80: 0.1/12; CrCl 50-79; 0.1/12; CrCl: 30-49; 0.1/12; CrCl:10-29: 0.1/12;
- 40 % of dose will be excreted in urine (w/ nl R F(x)) over 72 hrs;
- peds: > 8yrs: 5 mg/kg/day PO or IV, divided q 12hr; Contraindicated in pregnancy and in children < 8yrs;
- supplied: tabs: 50mg, 100mg; caps: 50mg, 100mg; powder for injection 100mg, 200mg per vial;
- take with food to avoid nausea;
- Hazards:
- photosensitivity;
- absorption will be decreased by aluminum, iron, bismuth, and Mg salts;
- half life decreased by barbituates, phenytoin, and tegertol, and bicarbonate will decrease
absorption and incr clearance of doxyclcline;
- digoxin will increase serum levels;
Minocycline-Induced Hyperpigmentation.
