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Wheeless' Textbook of Orthopaedics
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Class II Agents (Beta Blockers)




                          Dose (mg)   Interval     Specificity
  Acebutolol
  Atenolol                 50-100       daily       Cardioselective
  Esmolol
  Labetolol               200           bid
  Metoprolol               50-200       bid       Cardioselective
  Nadolol                 40-240       daily     Nonselective
  Pindolol                 10-30         bid       Nonselective
  Propanolol               10-80         qid       Nonselective
  Timolol                 10-30         bid       Nonselective


- Cautions and Interactions:
    - when discontinuing beta blockers, it is necessary to taper dose;
    - aspirin (by inhibiting prostacycline) will decrease the effectivness of class II agents;
    - beta-Adrenergic-receptor antagonists reduce the renal plasma flow & glomerular filtration rate & should
            therefore be avoided in pts with renal impairment;









Original Text by Clifford R. Wheeless, III, MD.