- for
PUD, prophylaxis in trauma, burns, surgery;
- Adult: active PUD: 300 mg PO/IV tid-qid, or 400 mg PO bid; - over 90% of ulcers should heal after 12 wks of therapy- Hosp Prac. 1979 - ulcers which have not healed after 12 wks, probably will not heal w/ H2 Blockers; - for recurrent duodenal Ulcer prophylaxis: 400 mg PO qhs; - active benign gastric ulcer: 300 mg PO qid or IV q6hr (over at least 2min); - w/ active ulcer: 300 mg PO qid w/ meals & hrs: 400mg bid or 800mg qhs; - chronic: 400 mg or 800 mg PO qhs; try after or w/ food or after retiring; - w/ Renal Failure/Elderly: 300mg IV bid;
Cimetidine: Interactions and Toxicities: - Cimedtidine (&
Ranitidine), inhibit the hepatic P-450 cytochrome system - May cause increased Blood Levels of: -
WARFARIN type anticoagulants -
theophylline - Phenytoin -
LIDOCAINE -
Propranolol -
metoprolol (
Class II) - Diazepam - Chlordiazepoxide - Will interact w/
Digoxin, * side effects: - intersitial nephritis, bone marrow dyscrasias, coma, severe hepatitis, - these are considered to be rare; * cimetidine is best avoided in pts w/ hepatic dz, jaundice; ---------------------------------
Review Article: Drug Therapy -- Histamine(sub 2)-Receptor Antagonists -- Standard Therapy For Acid-Peptic Diseases;
