The Hip: Preservation, Replacement and Revision

Chemotherapy Agents 

- Agents:
    - doxorubicin/adriamycin:
    - cis platin
    - methotrexate:

- Neoadjuvant Chemotherapy:
    - may facilitate limb salvage surgery by causing significant necrosis of the primary tumor;
    - protocol:
           - cis platin: 2 intra-arterial cycles are given at a dose of 120 mg;
           - doxorubicin given 20 mg qd for 3 days;

- Musculoskeletal Tumors which are Treated w/ Chemotherapy:
    - osteosarcoma
           - typically requires 3 cycles of chemotherapy;
    - malignant fibrous histiocytoma
    - ewing's sarcoma
           - typically requires 4 cycles of chemo;
    - multiple myeloma:

- Musculoskeletal Tumors which are Not Treated w/ Chemotherapy:
    - chondrosarcoma

The effect of chemotherapy on growth in the skeletally immature individual.

Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Monday, December 19, 2011 2:59 pm