- Agents:
-
doxorubicin/adriamycin:
-
cis platin
-
methotrexate:
- Neoadjuvant Chemotherapy:
- may facilitate limb salvage surgery by causing significant necrosis of the primary tumor;
-
protocol:
-
cis platin: 2 intra-arterial cycles are given at a dose of 120 mg;
-
doxorubicin given 20 mg qd for 3 days;
- Musculoskeletal Tumors which are Treated w/ Chemotherapy:
-
osteosarcoma
- typically requires 3 cycles of chemotherapy;
-
malignant fibrous histiocytoma
-
ewing's sarcoma
- typically requires 4 cycles of chemo;
-
multiple myeloma:
- Musculoskeletal Tumors which are Not Treated w/ Chemotherapy:
-
chondrosarcoma
The effect of chemotherapy on growth in the skeletally immature individual.
