- Discussion:
-
third generation cephalosporin;
- adult: 1-2gm IV q12-24hr; t1/2=7.5hr; w/ long half life, allows once a day dosing, and home treatment;
- peds: 100 mg/kg/day q12 or q24hr;
- no need to change w/ renal failure;
- broad spectrum Gm neg and positive organisms;
- good diffusion from blood into CSF only w/ inflammation;
- dosing Regimens for Patients with Renal Insufficiency: (Dose for 70kg Adult {gm/dosing interval
in hours}):CrCl:>80:1/12-24; CrCl:50-79:1/12-24; CrCl:30-49:1/12-24; CrCl:10-29::1/12-24;
- after dialysis give 1gm supplemental dose;
- 43 % of dose will be excreted in urine (w/ nl R F(x))
Penetration of ceftriaxone into the intervertebral disc.
