Causes of Hypercalcemia


- See:
   - Ossification of Soft Tissue and Periosteum
    - Metastatic Bone Tumors (prostate, thyroid, kidney, breast, lung)
    - Hyperparathyroidism
    - PTH secreting tumors (lung, kidney, ovary, colon), multiple myeloma
    - Vitamin D
           - amount of Vit D required to produce HyperCa is > 50,000 U/week;
    - Vitamin A
    - Ca excess
    - Osteoporosis, Immobilization, Milk alkalisyndrome (antacids)
    - Paget's dz
    - Idiopathic hypercalcemia of infants, Infantile Hypo-phosphatasia,
    - Thiazide meds
    - Chronic RF
    - Sarcoidosis
          - 10% of patients may have hyperCa
          - 50% will have hyperuricemia;
    - Adrenal insufficiency
    - Acromegaly
    - Estrogens and antiestrogens
           - cause hypercalcemia in approximately 30% of patients when used to treat breast cancer, which is metastatic to the skeleton;
    - Lithium:
           - hypercalcemia may occur with doses greater than 900 mg/day;
    - Milk-Alkali Syndrome:
           - may occur with large consumption of milk and calcium alkaline salts (usually calcium carbonate);
    - Hyperthyroidism
    - Bed Rest: (spine injury);
           - may cause hypercalciuria



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Tuesday, September 4, 2012 11:19 am