- Discussion: growth involves either or both of two processes;
-
Appositional Growth:
- new cartilage is formed at cartilage surface by cells derived from
chondroblasts of perichondrium;
- w/ maturation, majority of cartilage growth is primarily appositional;
-
Interstitial Growth:
- increase in internal mass of cartilage by activity of chondrocytes that
multiply within their lacunae;
- in mature cartilage, cellular turnover rate is exceedingly low;
- protein polysaccharide undergoes constant synthesis and degraded;
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Metatropic dwarfism. Uncoupling of endochondral and perichondral growth.
Characterization of aggregating proteoglycans from the proliferative,
maturing, hypertrophic, and calcifying zones of the cartilaginous physis.
