Year Book: Antibiotic Resistance of Biomaterial-Adherent Coagulase-Negative

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and Coagulase-Positive Staphylococci. Naylor-PT. Myrvik-QN. Gristina-A. 1992 Year Book of Orthopedics. Article 4-37. Original Article: Clin Orthop. 1990. 261. pp 126-133. ABSTRACT Background.--Microbial adhesion to biomaterial substrata is responsible for many resistant biomaterial-localized infections. Although the mechanisms by which bacterial surface populations acquire antibiotic and biocide resistance is unclear, it is clear that surface populations have different physiology and behavior than suspension populations. The antibiotic sensitivity and killing kinetics of pathogens retrieved from the surface of biomaterials in human infections were compared with those of suspended bacterial populations.