Vitamin A and wound healing

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Hunt TK. x Journal of the American Academy of Dermatology. 15(4 Pt 2):817 -21, 1986 Oct. Retinoids have long been associated with wound healing, but objective x data, until recently, have been scarce. Vitamin A deficiency retards x repair. Secondly, retinoids restore steroid-retarded repair toward normal. x Because vitamin A tends to suppress fibroblasts in cell culture and x stimulate steroid-treated macrophages to initiate reparative behavior in x tissue, we favor the hypothesis that retinoids are particularly important x in macrophagic inflammation, which plays a central role in the control of x wound healing. Probably all patients who take anti-inflammatory steroids x should control their retinoid intake, but how they should control it is as x yet unknown. x