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Wheeless' Textbook of Orthopaedics
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Vitamin A


- Discussion: - it is also required in appropriate amounts for membrane stability; - excess or defeciency may lead to rupture of lysosomal membranes; - Vit A participates in the biology of epithelium, and in excess it causes proliferation of basal cells and hyperkeratinization; - Toxicity: - causes increased intracranial pressure, vomiting, and lethargy; ----------------------- Effect of supplemental vitamin A on colon anastomotic healing in rats given preoperative irradiation. Restoration of collagen formation in photodamaged human skin by tretinoin Vitamin A and wound healing. Vitamin A and wound healing. Cortisone, vitamin A, and wound healing: the importance of measuring wound surface area. Supplemental vitamin A prevents the acute radiation-induced defect in wound healing. Effects of chronic corticosteroids and vitamin A on the healing of intestinal anastomoses. Supplemental vitamin A prevents the tumor-induced defect in wound healing. Impaired wound healing in streptozotocin diabetes. Prevention by supplemental vitamin A. The effect of methylprednisolone and vitamin A on wound healing. II. The effect of methylprednisolone and vitamin A on wound healing. I.



Original Text by Clifford R. Wheeless, III, MD.