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Wheeless' Textbook of Orthopaedics
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Type III Collagen



- See: Collagen Discussion:

- Discussion:
    - in Dupuytren's, there is an increase in type III collagen (which is similar to scar tissue);
          - normal fascia is mostly of type I collagen;
    - Ehlers-Danlos Syndrome:
          - see collagen disorders;
          - at least 9 types of Ehlers-Danlos syndrome have been defined;
          - mutations in Type III collagen may result in a of lethal form of Ehlers-Danlos syndrome;
          - most severe form is known as Type IV and is characterized by sudden rupture of large arteries or intestines;
                  - since the strength of large arteries depends largely on fibrils of type III collagen, it is possible that some forms
                        of type IV Ehlers-Danlos syndrome result from mutations in the type III collagen gene;




















Original Text by Clifford R. Wheeless, III, MD.