- principal metabolite of arachidonic acid in platelets;
- stimulates platelet activation, and assists in intravascular aggregation of platelets;
- ASA irreversibly inhibits cyclooxygenase by acetylation of serine residue at its active site;
- cyclooxygenase must be continuously produced in endothelial cells, since they recover their ability to synthesize Prostacyclin within a
- platelets cannot produce cyclooxygenase, & thromboxane synthesis recovers only as new platelets enter circulation
Original Text by Clifford R. Wheeless, III, MD.
Last updated by Data Trace Staff on Tuesday, August 30, 2011 12:46 pm