The significance of perioperative cultures in open pediatric lower-extremity

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fractures. Kreder HJ. Armstrong P. Clinical Orthopaedics & Related Research. (302):206-12, 1994 May. The value of perioperative cultures in 86 open pediatric lower-extremity fractures was assessed. Thirteen infections were identified, for an incidence of 15%. The predebridement culture was positive in 63% of wounds, and the postdebridement culture was positive in 40%. In the 13 wounds with infection, the infecting pathogen was found among the Á organisms grown on positive predebridement cultures 29% of the time, and  on 60% of post-debridement cultures. Neither culture was of value in predicting the identity of a potential subsequent infecting pathogen. There was no significant difference in the rate of infection for negative cultures versus positive cultures; however, a negative predebridement culture was associated with a 94% chance of avoiding infection, and a negative postdebridement culture correlated with a 79% probability that infection would not occur. A positive culture result was less useful, however, because the infection rate remained low in these instances. Predebridement cultures were highly sensitive (88%) in identifying wounds that developed infection; however, the false positive rate was high, resulting in a specificity of only 43%. Postdebridement cultures, although somewhat more specific (63%), lacked sensitivity (50%). Clearly the * routine use of perioperative cultures in open pediatric lower-extremity fractures must be questioned. Further prospective study is needed to Á confirm the validity and general applicability of the results of this retrospective review. *