- for Rheumatoid and Osteoarthritis, and anlkylosing spondylitis;
- Acute Gouty Arthritis;
- Acute Bursitis/subacromial buritis or tendinitis/supraspinatus tendinitis;
-
NSAIA; Dose:150-200mg PO bid with food;
- increaseas needed to maximum 400mg/day;
- Should be administered with food;
- Contraindicated with: patients w/ h/o asthma, urticaria, or rhinitis
precipitated by ASA or
NSAIA;
- Contra w/ PUD, and GI bleeding (can occur w/ Sulindac), hemhorrhagic
disorders, elderly;
- Closely monitor patients w/ HTN, impaired Renal F(x), hepatic F(x),
Cardiac F(x) or in any condition predisposing to fluid retention;
- Ineracts w/ oral anticoagulants to increase PT, reduce dose w/ renal
impairment;
- Supplied: 150, 200 mg;
- is a pro-drugs, with the active drug being produced in vivo;
-
becuase sulindac does not seem to affect renal synthesis of prostaglandins
as much as other NSAIDs, it should be preferred in patients with renal
disease or threatened renal perfusion, such as those who are
hypovolemic;
Effects of sulindac and ibuprofen in patients with chronic glomerular
disease.
Ciabattoni G, Cinotti GA, Pierucci A, et al.
N Engl J Med 1984; 310:279-83.
