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Wheeless' Textbook of Orthopaedics

Streptococcus

 - Discussion:
    - gram positive coccus
    - may be responsible for toxic shock syndrome and necrotizing fascitis
           - references:
                   - Fatal group A streptococcal infection with toxic shock syndrome: complicating minor orthopedic trauma.
                   - Streptococcal Toxic Shock Syndrome Presenting as Septic Knee Arthritis in a 5-Year-Old Child.
                   - Severe group A streptococcal infection and streptococcal toxic shock syndrome.
                   - Orthopaedic manifestations of invasive group A streptococcal infections complicating primary varicella
                   - Case 2-2009 — A 25-Year-Old Man with Pain and Swelling of the Right Hand and Hypotension

    - spetrum of streptococci pyogenes infections:
           - most common cause of celluitis and lymphangitis;
           - superficial form of infection is called impetigo which affects stratum corneum;
           - ecthyma contagiosum describes shallow superficial dermal ulcers caused by a slightly deeper infectios;
           - erysipelas is the term for streptococcal dermal cellulitis, often associated with lymphangitis as it spreads along dermal lymphatics;
                   - cellulitis can spread to the dermal lymphatics as classical lymphangitis, commonly causeced by strep pyogenes;
           - necrotizing streptococal infections:
                   - acute gangrene: at level of fascia, streptococci pyogenes, produces acute gangrene, a form of necrotizing fascitis;
                   - look for early rapid onset of marked tissue edema and redness w/ little pain, progressing to local
                          cyanosis & skin blistering;
                   - lymphangitis and lymphadenopathy are absent;
                   - soft tissue gas may be uncommon;
                   - treatment is parental penicillin, debridement, and measures to prevent edema;
                   - before antibiotics were available this was a surgical emergency mandating immediate amputation to
                          prevent streptococcal septicemia and death; 
           - group A strep: 
                   -
ref: - Group A Streptococcal (GAS) Disease


           - group B strep:
                   - e-medicine: Streptococcus Group B Infections 
                   - Relapsing invasive group B streptococcal infection in adults.
                   - Group B streptococcal vertebral osteomyelitis with bacteremia.
                   - Group B streptococcal osteomyelitis in adults.
                   - Vertebral osteomyelitis caused by group B streptococci (Streptococcus agalactiae) secondary to urinary tract infection. 
                   - Group B streptococcal prosthetic joint infections


 

Streptococcus pneumoniae
    - A prosthetic joint infection caused by Streptococcus pneumoniae: a case report and review of the literature
    - Bone and joint infection due to Streptococcus pneumoniae in two immunocompetent adults.
    - Pneumococcal septic arthritis: review of 190 cases


 

- Antibiotic Choices:

 


 

Group A beta-hemolytic streptococcal osteomyelitis in children.

Streptococcus viridans vertebral osteomyelitis.

Bacteremia complicated by vertebral osteomyelitis due to Streptococcus bovis.

Recurrent vertebral OM and psoas abscess caused by Strep constellatus and Fusobacterium nucleatum in a patient w/ atrial septal defect and an occult dental infection.

Clinical and diagnostic features of osteomyelitis occurring in the first three months of life.

Successful antimicrobial therapy and implant retention for streptococcal infection of prosthetic joints

Late Streptococcus bovis infection of knee arthroplasty and its association with carcinoma of the colon: a case report

Late infection of a total knee arthroplasty with Streptococcus bovis in association with carcinoma of the large intestine.

Streptococcus bovis-infected total hip arthroplasty

Group C streptococcal infection in a prosthetic joint


    - Pen G
    - 1st Generation Cephalsporins
    - Clindamycin
    - Erythromycin
    - Penase Res Penicillins
    - Chloramphenicol
    - Vancomycin
    - Rifampin

- Misc:
    - sulfa-derived antibiotics (sulfonamides / trimethoprim) are not generally effective in treating streptococcus infections;



Original Text by Clifford R. Wheeless, III, MD.

Last updated by Clifford R. Wheeless, III, MD on Thursday, January 15, 2009 9:35 pm