- is a coagulase negative, gram positive organism;
- has emerged as one of the most common organisms in total joint infections (and in other implanted devices);
- it is often minimally toxic (as compared to other bacterial infections), and many patients will have minimal symptoms of infection;
- it is particularly prone to recurrence following joint replantation;
- ref: Infection in total joint replacements. Why we screen MRSA when MRSE is the problem?
- biofilm and colonization of implants:
- its high recurrence rate may be related to its propensity to form a biofilm layer (extra-cellular glycocalyx) which coats the
bacteria, which protects by engulfment by neutrophils;
- slime layer may make antibiotic penetration and bacteria eradication more difficult;
- Adherence of Staphylococcus epidermidis to biomaterials is augmented by PIA.
- Occurrence of ica genes for slime in a collection of Staph epidermidis strains from orthopedic prosthesis infections.
- Surgical biomaterials and differential colonization by Staphylococcus epidermidis.
- Bacterial adherence to bioinert and bioactive materials studied in vitro.
- SdrF, a Staphylococcus epidermidis surface protein, binds type I collagen.
- Identification and preliminary characterization of cell-wall-anchored proteins of Staphylococcus epidermidis.
- Screening for S. epi markers discriminating between flora strains and those responsible for infections of joint prostheses.
- S epi in orthopedic device infections: the role of bacterial internalization in human osteoblasts and biofilm formation.
- Medical Intelligence: Emergence of Vancomycin Resistance In Coagulase-Negative Staphylococci.
- [Linezolid in the treatment of antibiotic-resistant gram-positive infections of the musculoskeletal system.]
- treatment of staph implant related infection:
- in the report by Konig, et al, authors report on success of a single case of staph epi infection over an orthopaedic implant
w/ combo of rifampin and cipro;
- Treatment of staphylococcal implant infection with rifampicin-ciprofloxacin in stable implants.
- Antibiotic susceptibility among S epidermidis isolated from prosthetic joint infections, with focus on doxycycline.
- Vancomycin resistant Staphylococcus epidermidis caused prosthesis infection. Linezolid and rifampicin healed the
- Foreign body infections due to Staphylococcus epidermidis.
- Time-dependent effects of rifampicin on staphylococcal biofilms
- Rifampicin enhances activity of daptomycin and vancomycin against both a polysaccharide intercellular adhesin (PIA)-dependent and -independent Staphylococcus epidermidis biofilm.
- Antibiotic susceptibility among Staphylococcus epidermidis isolated from prosthetic joint infections, with focus on doxycycline.
- chlorohexidene prep:
- Decreased susceptibility to chlorhexidine and prevalence of disinfectant resistance genes among clinical isolates of Staphylococcus epidermidis.
Does surgical prophylaxis with teicoplanin constitute a therapeutic advance?
Impetigo contagiosa III. Comparative efficacy of oral erythromycin and topical mupirocin.
Antimicrobial susceptibility of coagulase-negative staphylococci on tissue allografts and isolates from orthopedic patients.
Antibiotic resistance in exopolysaccharide-forming Staphylococcus epidermidis clinical isolates from orthopaedic implant infections.
Original Text by Clifford R. Wheeless, III, MD.
Last updated by Data Trace Staff on Monday, May 1, 2017 6:23 am