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Wheeless' Textbook of Orthopaedics
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Sodium Polystyrene Sulfonate/Kayexalate


- Discussion: - is a potassium removing resin, for hyperkalemia; - works as cation exchange resin, Na for K; - because of its delayed action, a cation exchange resin such as sodium sulfonate should be used only in mild cases of hyperkalemia or in catabolic patients with continuous release of intracellular potassium; - Precautions: - caution w/ CHF, marked edema, or severe HTN, due to high Na load; - must monitor K, Mg, and Ca; (hypomagnesemia & hypocalcemia) - concomitant administration of MgOH, non-absorbable cation donating antacids, and laxatives should be avoided; (See SORBITOL) - Dosage: - dose of 15 to 20 gm tid to qid may be taken orally or by retention enema; - adult: 15gm-60gm PO suspension (3-4ml/gm) q6hr prn; - 70% sorbitol solution is given concurrently to prevent fecal impaction;



Original Text by Clifford R. Wheeless, III, MD.