Protamine sulfate

- Discussion: 
- Reversal of Heparin effect; binds heparin within 5min of IV infusions (give slowly as 2mg/ml solution in saline); 
- Monitor PTT for effects; 
- Protamine sulfate itself has anticoagulant properties, hence judge needed amount conservatively; 
- Precautions: 
- hypotension may result from rapid infusion;

- watch for anaphylactoid like reactions; 
- Dose: 
- based on amount of heparin reversal desired;

- given slowly IV, 1 mg will reverse approx 100 units of heparin given in over 3-4hr to max dose of 50 mg in any 10 min period, or 200 mg w/ in 2hrs; 
- no more than 100 mg should be given except in extreme circumstances

Original Text by Clifford R. Wheeless, III, MD.

Last updated by Data Trace Staff on Monday, December 19, 2011 12:48 pm