- Discussion: - Reversal of
Heparin effect; binds heparin within 5min of IV infusions (give slowly as 2mg/ml solution in saline); - Monitor
PTT for effects; - Protamine sulfate itself has anticoagulant properties, hence judge needed amount conservatively;
- Precautions: - hypotension may result from rapid infusion; - watch for anaphylactoid like reactions;
- Dose: - based on amount of heparin reversal desired; - given slowly IV, 1 mg will reverse approx 100 units of heparin given in over 3-4hr to max dose of 50 mg in any 10 min period, or 200 mg w/ in 2hrs; - no more than 100 mg should be given except in extreme circumstances;
